Cargando…
High-throughput characterization of genetic effects on DNA–protein binding and gene transcription
Many variants associated with complex traits are in noncoding regions and contribute to phenotypes by disrupting regulatory sequences. To characterize these variants, we developed a streamlined protocol for a high-throughput reporter assay, Biallelic Targeted STARR-seq (BiT-STARR-seq), that identifi...
Autores principales: | Kalita, Cynthia A., Brown, Christopher D., Freiman, Andrew, Isherwood, Jenna, Wen, Xiaoquan, Pique-Regi, Roger, Luca, Francesca |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211638/ https://www.ncbi.nlm.nih.gov/pubmed/30254052 http://dx.doi.org/10.1101/gr.237354.118 |
Ejemplares similares
-
Which Genetics Variants in DNase-Seq Footprints Are More Likely to Alter Binding?
por: Moyerbrailean, Gregory A., et al.
Publicado: (2016) -
PTWAS: investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis
por: Zhang, Yuhua, et al.
Publicado: (2020) -
Integrating molecular QTL data into genome-wide genetic association analysis: Probabilistic assessment of enrichment and colocalization
por: Wen, Xiaoquan, et al.
Publicado: (2017) -
Cross-Population Joint Analysis of eQTLs: Fine Mapping and Functional Annotation
por: Wen, Xiaoquan, et al.
Publicado: (2015) -
High-throughput allele-specific expression across 250 environmental conditions
por: Moyerbrailean, Gregory A., et al.
Publicado: (2016)