Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke

BACKGROUND AND PURPOSE: Polymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that genetic variation in the endothelial-based receptors of the thrombomodulin−protein C system (THBD and PROCR) may similarly be associated with e...

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Detalles Bibliográficos
Autores principales: Cole, John W., Xu, Huichun, Ryan, Kathleen, Jaworek, Thomas, Dueker, Nicole, McArdle, Patrick, Gaynor, Brady, Cheng, Yu-Ching, O'Connell, Jeffrey, Bevan, Steve, Malik, Rainer, Ahmed, Naveed Uddin, Amouyel, Philippe, Anjum, Sheraz, Bis, Joshua C., Crosslin, David, Danesh, John, Engelter, Stefan T., Fornage, Myriam, Frossard, Philippe, Gieger, Christian, Giese, Anne-Katrin, Grond-Ginsbach, Caspar, Ho, Weang Kee, Holliday, Elizabeth, Hopewell, Jemma, Hussain, M., Iqbal, W., Jabeen, S., Jannes, Jim, Kamal, Ayeesha, Kamatani, Yoichiro, Kanse, Sandip, Kloss, Manja, Lathrop, Mark, Leys, Didier, Lindgren, Arne, Longstreth, W. T., Mahmood, Khalid, Meisinger, Christa, Metso, Tiina M., Mosley, Thomas, Müller-Nurasyid, Martina, Norrving, Bo, Parati, Eugenio, Peters, Annette, Pezzini, Alessandro, Quereshi, I., Rasheed, Asif, Rauf, A., Salam, T., Shen, Jess, Słowik, Agnieszka, Stanne, Tara, Strauch, Konstantin, Tatlisumak, Turgut, Thijs, Vincent N., Tiedt, Steffen, Traylor, Matthew, Waldenberger, Melanie, Walters, Matthew, Zhao, Wei, Boncoraglio, Giorgio, Debette, Stéphanie, Jern, Christina, Levi, Christopher, Markus, Hugh, Meschia, James, Rolfs, Arndt, Rothwell, Peter, Saleheen, Danish, Seshadri, Sudha, Sharma, Pankaj, Sudlow, Cathie, Worrall, Bradford, Stine, O. Colin, Kittner, Steven J., Mitchell, Braxton D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211695/
https://www.ncbi.nlm.nih.gov/pubmed/30383853
http://dx.doi.org/10.1371/journal.pone.0206554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211695/
https://www.ncbi.nlm.nih.gov/pubmed/30383853
http://dx.doi.org/10.1371/journal.pone.0206554

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