Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis

Intestinal mucus layer disruption and gut microflora modification in conjunction with tight junction (TJ) changes can increase colonic permeability that allows bacterial dissemination and intestinal and systemic disease. We showed previously that Citrobacter rodentium (CR)-induced colonic crypt hype...

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Detalles Bibliográficos
Autores principales: Ahmed, Ishfaq, Roy, Badal C., Raach, Rita-Marie T., Owens, Sarah M., Xia, Lijun, Anant, Shrikant, Sampath, Venkatesh, Umar, Shahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211731/
https://www.ncbi.nlm.nih.gov/pubmed/30383855
http://dx.doi.org/10.1371/journal.pone.0206701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211731/
https://www.ncbi.nlm.nih.gov/pubmed/30383855
http://dx.doi.org/10.1371/journal.pone.0206701

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