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Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents

The development of novel therapeutics is urgently required for diseases where existing treatments are failing due to the emergence of resistance. This is particularly pertinent for parasitic infections of the tropics and sub-tropics, referred to collectively as neglected tropical diseases, where the...

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Detalles Bibliográficos
Autores principales: Giuliani, Sandra, Silva, Arthur C., Borba, Joyce V. V. B., Ramos, Pablo I. P., Paveley, Ross A., Muratov, Eugene N., Andrade, Carolina Horta, Furnham, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211772/
https://www.ncbi.nlm.nih.gov/pubmed/30346968
http://dx.doi.org/10.1371/journal.pcbi.1006515