Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function

The dynein-2 microtubule motor is the retrograde motor for intraflagellar transport. Mutations in dynein-2 components cause skeletal ciliopathies, notably Jeune syndrome. Dynein-2 contains a heterodimer of two non-identical intermediate chains, WDR34 and WDR60. Here, we use knockout cell lines to de...

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Detalles Bibliográficos
Autores principales: Vuolo, Laura, Stevenson, Nicola L, Heesom, Kate J, Stephens, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211827/
https://www.ncbi.nlm.nih.gov/pubmed/30320547
http://dx.doi.org/10.7554/eLife.39655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211827/
https://www.ncbi.nlm.nih.gov/pubmed/30320547
http://dx.doi.org/10.7554/eLife.39655

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