Screening of candidate substrates and coupling ions of transporters by thermostability shift assays

Substrates of most transport proteins have not been identified, limiting our understanding of their role in physiology and disease. Traditional identification methods use transport assays with radioactive compounds, but they are technically challenging and many compounds are unavailable in radioacti...

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Detalles Bibliográficos
Autores principales: Majd, Homa, King, Martin S, Palmer, Shane M, Smith, Anthony C, Elbourne, Liam DH, Paulsen, Ian T, Sharples, David, Henderson, Peter JF, Kunji, Edmund RS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211832/
https://www.ncbi.nlm.nih.gov/pubmed/30320551
http://dx.doi.org/10.7554/eLife.38821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211832/
https://www.ncbi.nlm.nih.gov/pubmed/30320551
http://dx.doi.org/10.7554/eLife.38821

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