Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Small heat shock proteins (sHSPs) are a class of oligomeric molecular chaperones that limit protein aggregation. However, it is often not clear where sHSPs bind on their client proteins or how these protein-protein interactions (PPIs) are regulated. Here, we map the PPIs between human Hsp27 and the...

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Detalles Bibliográficos
Autores principales: Freilich, Rebecca, Betegon, Miguel, Tse, Eric, Mok, Sue-Ann, Julien, Olivier, Agard, David A., Southworth, Daniel R., Takeuchi, Koh, Gestwicki, Jason E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212398/
https://www.ncbi.nlm.nih.gov/pubmed/30385828
http://dx.doi.org/10.1038/s41467-018-07012-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212398/
https://www.ncbi.nlm.nih.gov/pubmed/30385828
http://dx.doi.org/10.1038/s41467-018-07012-4

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