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MMP-1 overexpression selectively alters inhibition in D1 spiny projection neurons in the mouse nucleus accumbens core

Protease activated receptor-1 (PAR-1) and its ligand, matrix metalloproteinase-1 (MMP-1), are altered in several neurodegenerative diseases. PAR-1/MMP-1 signaling impacts neuronal activity in various brain regions, but their role in regulating synaptic physiology in the ventral striatum, which is im...

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Detalles Bibliográficos
Autores principales: Al-muhtasib, Nour, Forcelli, Patrick A., Conant, Katherine E., Vicini, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212422/
https://www.ncbi.nlm.nih.gov/pubmed/30385861
http://dx.doi.org/10.1038/s41598-018-34551-z