The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson’s disease

Accumulation of alpha-synuclein (ASYN) in neurons and other CNS cell types may contribute to the underlying pathology of synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and Multiple Systems Atrophy (MSA). In support of this hypothesis for PD, ASYN immunopositive...

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Detalles Bibliográficos
Autores principales: Price, Diana L., Koike, Maya A., Khan, Asma, Wrasidlo, Wolfgang, Rockenstein, Edward, Masliah, Eliezer, Bonhaus, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212487/
https://www.ncbi.nlm.nih.gov/pubmed/30385782
http://dx.doi.org/10.1038/s41598-018-34490-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212487/
https://www.ncbi.nlm.nih.gov/pubmed/30385782
http://dx.doi.org/10.1038/s41598-018-34490-9

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