Real-Time MRI Guidance for Reproducible Hyperosmolar Opening of the Blood-Brain Barrier in Mice

The blood-brain barrier (BBB) prevents effective delivery of most therapeutic agents to the brain. Intra-arterial (IA) infusion of hyperosmotic mannitol has been widely used to open the BBB and improve parenchymal targeting, but the extent of BBB disruption has varied widely with therapeutic outcome...

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Detalles Bibliográficos
Autores principales: Chu, Chengyan, Liu, Guanshu, Janowski, Miroslaw, Bulte, Jeff W. M., Li, Shen, Pearl, Monica, Walczak, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212512/
https://www.ncbi.nlm.nih.gov/pubmed/30416485
http://dx.doi.org/10.3389/fneur.2018.00921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212512/
https://www.ncbi.nlm.nih.gov/pubmed/30416485
http://dx.doi.org/10.3389/fneur.2018.00921

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