TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw

Giant cell lesions of the jaw (GCLJ) are debilitating tumors of unknown origin with limited available therapies. Here, we analyze 58 sporadic samples using next generation or targeted sequencing and report somatic, heterozygous, gain-of-function mutations in KRAS, FGFR1, and p.M713V/I-TRPV4 in 72% (...

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Detalles Bibliográficos
Autores principales: Gomes, Carolina Cavalieri, Gayden, Tenzin, Bajic, Andrea, Harraz, Osama F., Pratt, Jonathan, Nikbakht, Hamid, Bareke, Eric, Diniz, Marina Gonçalves, Castro, Wagner Henriques, St-Onge, Pascal, Sinnett, Daniel, Han, HyeRim, Rivera, Barbara, Mikael, Leonie G., De Jay, Nicolas, Kleinman, Claudia L., Valera, Elvis Terci, Bassenden, Angelia V., Berghuis, Albert M., Majewski, Jacek, Nelson, Mark T., Gomez, Ricardo Santiago, Jabado, Nada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212533/
https://www.ncbi.nlm.nih.gov/pubmed/30385747
http://dx.doi.org/10.1038/s41467-018-06690-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212533/
https://www.ncbi.nlm.nih.gov/pubmed/30385747
http://dx.doi.org/10.1038/s41467-018-06690-4

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