Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism

Due to the lack of effective treatments for glioblastoma (GBM), we here studied the responsiveness of GBM cell lines to the combination of death ligand, TRAIL and the IAP antagonist, TL32711 (Birinapant). Responses were highly heterogeneous, with synergistic apoptosis as well as treatment resistance...

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Detalles Bibliográficos
Autores principales: Lincoln, Frank A., Imig, Dirke, Boccellato, Chiara, Juric, Viktorija, Noonan, Janis, Kontermann, Roland E., Allgöwer, Frank, Murphy, Brona M., Rehm, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212537/
https://www.ncbi.nlm.nih.gov/pubmed/30385739
http://dx.doi.org/10.1038/s41419-018-1160-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212537/
https://www.ncbi.nlm.nih.gov/pubmed/30385739
http://dx.doi.org/10.1038/s41419-018-1160-2

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