Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2

Although hepatoprotective properties of silybin are well documented, the clinical therapeutic efficacy is limited by its low bioavailability due to absorption rates, extensive phase II metabolism, and biliary excretion. As our previous study indicated that metabolic enzymes may have limited effects...

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Detalles Bibliográficos
Autores principales: Xu, Peng, Zhou, Hua, Li, Ya-Zhuo, Yuan, Zhong-Wen, Liu, Chang-Xiao, Liu, Liang, Xie, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212553/
https://www.ncbi.nlm.nih.gov/pubmed/30416442
http://dx.doi.org/10.3389/fphar.2018.01115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212553/
https://www.ncbi.nlm.nih.gov/pubmed/30416442
http://dx.doi.org/10.3389/fphar.2018.01115

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