Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells

c-MYC proto-oncogene harbours a transcription-inhibitory quadruplex-forming scaffold (Pu27) upstream P(1) promoter providing anti-neoplastic therapeutic target. Previous reports showed the binding profile of human Cathelicidin peptide (LL37) and telomeric G-quadruplex. Here, we truncated the quadrup...

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Detalles Bibliográficos
Autores principales: Sengupta, Pallabi, Banerjee, Nilanjan, Roychowdhury, Tanaya, Dutta, Anindya, Chattopadhyay, Samit, Chatterjee, Subhrangsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212778/
https://www.ncbi.nlm.nih.gov/pubmed/30239898
http://dx.doi.org/10.1093/nar/gky824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212778/
https://www.ncbi.nlm.nih.gov/pubmed/30239898
http://dx.doi.org/10.1093/nar/gky824

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