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Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells
c-MYC proto-oncogene harbours a transcription-inhibitory quadruplex-forming scaffold (Pu27) upstream P(1) promoter providing anti-neoplastic therapeutic target. Previous reports showed the binding profile of human Cathelicidin peptide (LL37) and telomeric G-quadruplex. Here, we truncated the quadrup...
Autores principales: | Sengupta, Pallabi, Banerjee, Nilanjan, Roychowdhury, Tanaya, Dutta, Anindya, Chattopadhyay, Samit, Chatterjee, Subhrangsu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212778/ https://www.ncbi.nlm.nih.gov/pubmed/30239898 http://dx.doi.org/10.1093/nar/gky824 |
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