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Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations
Current models for the folding of the human genome see a hierarchy stretching down from chromosome territories, through A/B compartments and topologically-associating domains (TADs), to contact domains stabilized by cohesin and CTCF. However, molecular mechanisms underlying this folding, and the way...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212781/ https://www.ncbi.nlm.nih.gov/pubmed/30239812 http://dx.doi.org/10.1093/nar/gky763 |