T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction

DNA ligases play essential roles in DNA replication and repair. Bacteriophage T4 DNA ligase is the first ATP-dependent ligase enzyme to be discovered and is widely used in molecular biology, but its structure remained unknown. Our crystal structure of T4 DNA ligase bound to DNA shows a compact α-hel...

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Detalles Bibliográficos
Autores principales: Shi, Ke, Bohl, Thomas E, Park, Jeonghyun, Zasada, Andrew, Malik, Shray, Banerjee, Surajit, Tran, Vincent, Li, Na, Yin, Zhiqi, Kurniawan, Fredy, Orellana, Kayo, Aihara, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212786/
https://www.ncbi.nlm.nih.gov/pubmed/30169742
http://dx.doi.org/10.1093/nar/gky776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212786/
https://www.ncbi.nlm.nih.gov/pubmed/30169742
http://dx.doi.org/10.1093/nar/gky776

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