A single molecule analysis of H-NS uncouples DNA binding affinity from DNA specificity

Heat-stable nucleoid structuring protein (H-NS) plays a crucial role in gene silencing within prokaryotic cells and is important in pathogenesis. It was reported that H-NS silences nearly 5% of the genome, yet the molecular mechanism of silencing is not well understood. Here, we employed a highly-se...

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Detalles Bibliográficos
Autores principales: Gulvady, Ranjit, Gao, Yunfeng, Kenney, Linda J, Yan, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212787/
https://www.ncbi.nlm.nih.gov/pubmed/30239908
http://dx.doi.org/10.1093/nar/gky826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212787/
https://www.ncbi.nlm.nih.gov/pubmed/30239908
http://dx.doi.org/10.1093/nar/gky826

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