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Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses

One paradigm to explain the complexity of viral RNA populations is that the low fidelity of the RNA-dependent RNA polymerase (RdRp) drives high mutation rates and consequently genetic diversity. Like most RNA viruses, wild-type yellow fever virus (YFV) replication is error-prone due to the lack of p...

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Detalles Bibliográficos
Autores principales: Collins, Natalie D., Beck, Andrew S., Widen, Steven G., Wood, Thomas G., Higgs, Stephen, Barrett, Alan D. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212827/
https://www.ncbi.nlm.nih.gov/pubmed/30377281
http://dx.doi.org/10.1128/mBio.01871-18