More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand

Guanine-rich nucleic acid sequences can fold into four-stranded G-quadruplex (G4) structures. Despite growing evidence for their biological significance, considerable work still needs to be done to detail their cellular occurrence and functions. Herein, we describe an optimized core-extended naphtha...

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Detalles Bibliográficos
Autores principales: Zuffo, Michela, Guédin, Aurore, Leriche, Emma-Dune, Doria, Filippo, Pirota, Valentina, Gabelica, Valérie, Mergny, Jean-Louis, Freccero, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212845/
https://www.ncbi.nlm.nih.gov/pubmed/29986058
http://dx.doi.org/10.1093/nar/gky607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212845/
https://www.ncbi.nlm.nih.gov/pubmed/29986058
http://dx.doi.org/10.1093/nar/gky607

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