Highly efficient genome editing via CRISPR–Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression

Genome editing of human induced pluripotent stem cells (iPSCs) is instrumental for functional genomics, disease modeling, and regenerative medicine. However, low editing efficiency has hampered the applications of CRISPR–Cas9 technology in creating knockin (KI) or knockout (KO) iPSC lines, which is...

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Detalles Bibliográficos
Autores principales: Li, Xiao-Lan, Li, Guo-Hua, Fu, Juan, Fu, Ya-Wen, Zhang, Lu, Chen, Wanqiu, Arakaki, Cameron, Zhang, Jian-Ping, Wen, Wei, Zhao, Mei, Chen, Weisheng V, Botimer, Gary D, Baylink, David, Aranda, Leslie, Choi, Hannah, Bechar, Rachel, Talbot, Prue, Sun, Chang-Kai, Cheng, Tao, Zhang, Xiao-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212847/
https://www.ncbi.nlm.nih.gov/pubmed/30239926
http://dx.doi.org/10.1093/nar/gky804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212847/
https://www.ncbi.nlm.nih.gov/pubmed/30239926
http://dx.doi.org/10.1093/nar/gky804

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