An Alanine-to-Valine Substitution in the Residue 175 of Zika Virus NS2A Protein Affects Viral RNA Synthesis and Attenuates the Virus In Vivo

The recent outbreaks of Zika virus (ZIKV), its association with Guillain–Barré syndrome and fetal abnormalities, and the lack of approved vaccines and antivirals, highlight the importance of developing countermeasures to combat ZIKV disease. In this respect, infectious clones constitute excellent to...

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Detalles Bibliográficos
Autores principales: Márquez-Jurado, Silvia, Nogales, Aitor, Ávila-Pérez, Ginés, Iborra, Francisco J., Martínez-Sobrido, Luis, Almazán, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212934/
https://www.ncbi.nlm.nih.gov/pubmed/30301244
http://dx.doi.org/10.3390/v10100547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212934/
https://www.ncbi.nlm.nih.gov/pubmed/30301244
http://dx.doi.org/10.3390/v10100547

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