APS8 Delays Tumor Growth in Mice by Inducing Apoptosis of Lung Adenocarcinoma Cells Expressing High Number of α7 Nicotinic Receptors

The alkylpyridinium polymer APS8, a potent antagonist of α7 nicotinic acetylcholine receptors (nAChRs), selectively induces apoptosis in non-small cell lung cancer cells but not in normal lung fibroblasts. To explore the potential therapeutic value of APS8 for at least certain types of lung cancer,...

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Detalles Bibliográficos
Autores principales: Berne, Sabina, Čemažar, Maja, Frangež, Robert, Juntes, Polona, Kranjc, Simona, Grandič, Marjana, Savarin, Monika, Turk, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213019/
https://www.ncbi.nlm.nih.gov/pubmed/30282908
http://dx.doi.org/10.3390/md16100367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213019/
https://www.ncbi.nlm.nih.gov/pubmed/30282908
http://dx.doi.org/10.3390/md16100367

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