The Pro-Oxidant Activity of Pheomelanin is Significantly Enhanced by UVA Irradiation: Benzothiazole Moieties Are More Reactive than Benzothiazine Moieties

It is generally considered that eumelanin (EM) is photoprotective while pheomelanin (PM) is phototoxic. A recent study using a mouse model demonstrated that PM produces reactive oxygen species (ROS) that cause DNA damage and eventually lead to melanomagenesis. A biochemical study showed that PM poss...

Descripción completa

Detalles Bibliográficos
Autores principales: Tanaka, Hitomi, Yamashita, Yui, Umezawa, Kana, Hirobe, Tomohisa, Ito, Shosuke, Wakamatsu, Kazumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213070/
https://www.ncbi.nlm.nih.gov/pubmed/30249034
http://dx.doi.org/10.3390/ijms19102889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213070/
https://www.ncbi.nlm.nih.gov/pubmed/30249034
http://dx.doi.org/10.3390/ijms19102889

Ejemplares similares