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The Pro-Oxidant Activity of Pheomelanin is Significantly Enhanced by UVA Irradiation: Benzothiazole Moieties Are More Reactive than Benzothiazine Moieties
It is generally considered that eumelanin (EM) is photoprotective while pheomelanin (PM) is phototoxic. A recent study using a mouse model demonstrated that PM produces reactive oxygen species (ROS) that cause DNA damage and eventually lead to melanomagenesis. A biochemical study showed that PM poss...
Autores principales: | Tanaka, Hitomi, Yamashita, Yui, Umezawa, Kana, Hirobe, Tomohisa, Ito, Shosuke, Wakamatsu, Kazumasa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213070/ https://www.ncbi.nlm.nih.gov/pubmed/30249034 http://dx.doi.org/10.3390/ijms19102889 |
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