Cargando…

Pharmacological Inhibition of Class IIA HDACs by LMK-235 in Pancreatic Neuroendocrine Tumor Cells

Histone deacetylases (HDACs) play a key role in epigenetic mechanisms in health and disease and their dysfunction is implied in several cancer entities. Analysis of expression patterns in pancreatic neuroendocrine tumors (pNETs) indicated HDAC5 to be a potential target for future therapies. As a fir...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wanek, Julia, Gaisberger, Martin, Beyreis, Marlena, Mayr, Christian, Helm, Katharina, Primavesi, Florian, Jäger, Tarkan, Di Fazio, Pietro, Jakab, Martin, Wagner, Andrej, Neureiter, Daniel, Kiesslich, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213165/ https://www.ncbi.nlm.nih.gov/pubmed/30321986 http://dx.doi.org/10.3390/ijms19103128

Ejemplares similares

HDAC-Linked “Proliferative” miRNA Expression Pattern in Pancreatic Neuroendocrine Tumors
por: Klieser, Eckhard, et al.
Publicado: (2018)

The Cancer Stem Cell Inhibitor Napabucasin (BBI608) Shows General Cytotoxicity in Biliary Tract Cancer Cells and Reduces Cancer Stem Cell Characteristics
por: Beyreis, Marlena, et al.
Publicado: (2019)

Miniaturization of the Clonogenic Assay Using Confluence Measurement
por: Mayr, Christian, et al.
Publicado: (2018)

Continuous, label-free, 96-well-based determination of cell migration using confluence measurement
por: Mayr, Christian, et al.
Publicado: (2018)

HDAC Screening Identifies the HDAC Class I Inhibitor Romidepsin as a Promising Epigenetic Drug for Biliary Tract Cancer
por: Mayr, Christian, et al.
Publicado: (2021)

HDAC inhibitor LMK-235 promotes the odontoblast differentiation of dental pulp cells
por: Liu, Zhao, et al.
Publicado: (2018)

Deregulated MicroRNAs in Biliary Tract Cancer: Functional Targets and Potential Biomarkers
por: Mayr, Christian, et al.
Publicado: (2016)

Acid- and Volume-Sensitive Chloride Currents in Microglial Cells
por: Kittl, Michael, et al.
Publicado: (2019)

Histone deacetylase inhibitor LMK235 attenuates vascular constriction and aortic remodelling in hypertension
por: Choi, Sin Young, et al.
Publicado: (2019)

Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells
por: Mayr, Christian, et al.
Publicado: (2023)

Long Non-Coding RNAs in Biliary Tract Cancer—An Up-to-Date Review
por: Bekric, Dino, et al.
Publicado: (2020)

Evaluation of Tazemetostat as a Therapeutically Relevant Substance in Biliary Tract Cancer
por: Bekric, Dino, et al.
Publicado: (2023)

Hot Spot TERT Promoter Mutations Are Rare in Sporadic Pancreatic Neuroendocrine Neoplasms and Associated with Telomere Length and Epigenetic Expression Patterns
por: Posch, Alexandra, et al.
Publicado: (2020)

Can We Efficiently Target HDAC in Cancer?
por: Kiesslich, Tobias, et al.
Publicado: (2022)

The green tea catechin epigallocatechin gallate induces cell cycle arrest and shows potential synergism with cisplatin in biliary tract cancer cells
por: Mayr, Christian, et al.
Publicado: (2015)

Thermographic real-time-monitoring of surgical radiofrequency and microwave ablation in a perfused porcine liver model
por: Primavesi, Florian, et al.
Publicado: (2018)

The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells
por: Mayr, Christian, et al.
Publicado: (2015)

Relevance of MicroRNA200 Family and MicroRNA205 for Epithelial to Mesenchymal Transition and Clinical Outcome in Biliary Tract Cancer Patients
por: Urbas, Romana, et al.
Publicado: (2016)

Pancreatic cancer in young adults: changes, challenges, and solutions
por: Primavesi, Florian, et al.
Publicado: (2019)

Class IIa HDACs in myelination
por: Velasco-Aviles, Sergio, et al.
Publicado: (2018)

Robust linear regression model of Ki-67 for mitotic rate in gastrointestinal stromal tumors
por: KEMMERLING, RALF, et al.
Publicado: (2014)

NRF2: The key to tumor- and patient-dependent chemosensitivity in biliary tract cancer?
por: Kiesslich, Tobias, et al.
Publicado: (2019)

The Crosstalk of miRNA and Oxidative Stress in the Liver: From Physiology to Pathology and Clinical Implications
por: Klieser, Eckhard, et al.
Publicado: (2019)

Morphologic and genic effects of waste pollution on the reproductive physiology of Paracentrotus lividus lmk: a mesocosm experiment
por: Glaviano, Francesca, et al.
Publicado: (2023)

Acid- and Volume-Sensitive Chloride Currents in Human Chondrocytes
por: Kittl, Michael, et al.
Publicado: (2020)

MicroRNAs Associated with the Efficacy of Photodynamic Therapy in Biliary Tract Cancer Cell Lines
por: Wagner, Andrej, et al.
Publicado: (2014)

Biliary tract cancer stem cells - translational options and challenges
por: Mayr, Christian, et al.
Publicado: (2017)

The potential predictive value of tumor budding for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer
por: Jäger, Tarkan, et al.
Publicado: (2018)

Global connectivity patterns of the notoriously invasive mussel, Mytilus galloprovincialis Lmk using archived CO1 sequence data
por: Pickett, Thomas, et al.
Publicado: (2018)

Immunmodulatory Treatment Strategies of Hepatocellular Carcinoma: From Checkpoint Inhibitors Now to an Integrated Approach in the Future
por: Ocker, Matthias, et al.
Publicado: (2021)

Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2
por: Jayathilaka, Nimanthi, et al.
Publicado: (2012)

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9
por: Lenoir, Olivia, et al.
Publicado: (2011)

The PEritoneal SUrface CAlculator (PESUCA): A new tool to quantify the resected peritoneal surface area after cytoreductive surgery
por: Schredl, Philipp, et al.
Publicado: (2020)

Expression of the microRNA-200 Family, microRNA-205, and Markers of Epithelial–Mesenchymal Transition as Predictors for Endoscopic Submucosal Dissection over Esophagectomy in Esophageal Adenocarcinoma: A Single-Center Experience
por: Neureiter, Daniel, et al.
Publicado: (2020)

Editorial: Novel therapeutic approaches for biliary tract cancer and hepatocellular carcinoma
por: Bekric, Dino, et al.
Publicado: (2023)

Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis
por: Clocchiatti, Andrea, et al.
Publicado: (2011)

Sub-Chronic Effects of Slight PAH- and PCB-Contaminated Mesocosms in Paracentrotus lividus Lmk: A Multi-Endpoint Approach and De Novo Transcriptomic
por: Albarano, Luisa, et al.
Publicado: (2021)

Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
por: Martin, Sheree D., et al.
Publicado: (2023)

Low VDAC1 Expression Is Associated with an Aggressive Phenotype and Reduced Overall Patient Survival in Cholangiocellular Carcinoma
por: Feichtinger, René Günther, et al.
Publicado: (2019)

Ferroptosis in Hepatocellular Carcinoma: Mechanisms, Drug Targets and Approaches to Clinical Translation
por: Bekric, Dino, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_oo53afi1ul9971i0rcdv35ec4q