Oxidative Alteration of Trp-214 and Lys-199 in Human Serum Albumin Increases Binding Affinity with Phenylbutazone: A Combined Experimental and Computational Investigation

Human serum albumin (HSA) is a target for reactive oxygen species (ROS), and alterations of its physiological functions caused by oxidation is a current issue. In this work, the amino-acid residues Trp-214 and Lys-199, which are located at site I of HSA, were experimentally and computationally oxidi...

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Detalles Bibliográficos
Autores principales: Bertozo, Luiza de Carvalho, Tavares Neto, Ernesto, de Oliveira, Leandro Cristante, Ximenes, Valdecir Farias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213266/
https://www.ncbi.nlm.nih.gov/pubmed/30241420
http://dx.doi.org/10.3390/ijms19102868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213266/
https://www.ncbi.nlm.nih.gov/pubmed/30241420
http://dx.doi.org/10.3390/ijms19102868

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