Nucleic Acid-Dependent Structural Transition of the Intrinsically Disordered N-Terminal Appended Domain of Human Lysyl-tRNA Synthetase

Eukaryotic lysyl-tRNA synthetases (LysRS) have an N-terminal appended tRNA-interaction domain (RID) that is absent in their prokaryotic counterparts. This domain is intrinsically disordered and lacks stable structures. The disorder-to-order transition is induced by tRNA binding and has implications...

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Detalles Bibliográficos
Autores principales: Kwon, Soon Bin, Yu, Ji Eun, Park, Chan, Lee, Jiseop, Seong, Baik L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213541/
https://www.ncbi.nlm.nih.gov/pubmed/30282926
http://dx.doi.org/10.3390/ijms19103016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213541/
https://www.ncbi.nlm.nih.gov/pubmed/30282926
http://dx.doi.org/10.3390/ijms19103016

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