Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Insulin therapy is often needed to overcome insulin receptor resistance in type 2 diabetes; however, the impact of providing additional insulin to already hyperinsulinemic subjects is not clear. We infused male TALLYHO/Jng (TH) mice (insulin resistant) with insulin (50 U/kg·bw/d) or vehicle (control...

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Detalles Bibliográficos
Autores principales: Fluitt, Maurice B., Rizvi, Sophia, Li, Lijun, Alunan, Ashley, Lee, Hwal, Tiwari, Swasti, Ecelbarger, Carolyn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213653/
https://www.ncbi.nlm.nih.gov/pubmed/30249002
http://dx.doi.org/10.3390/ijms19102880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213653/
https://www.ncbi.nlm.nih.gov/pubmed/30249002
http://dx.doi.org/10.3390/ijms19102880

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