Cargando…

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Insulin therapy is often needed to overcome insulin receptor resistance in type 2 diabetes; however, the impact of providing additional insulin to already hyperinsulinemic subjects is not clear. We infused male TALLYHO/Jng (TH) mice (insulin resistant) with insulin (50 U/kg·bw/d) or vehicle (control...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fluitt, Maurice B., Rizvi, Sophia, Li, Lijun, Alunan, Ashley, Lee, Hwal, Tiwari, Swasti, Ecelbarger, Carolyn M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213653/ https://www.ncbi.nlm.nih.gov/pubmed/30249002 http://dx.doi.org/10.3390/ijms19102880

Ejemplares similares

2466 MicroRNA-451: A potential key player in the development of diabetic nephropathy in an insulin resistant mouse model
por: Fluitt, Maurice B, et al.
Publicado: (2018)

Absence of renal enlargement in fructose‐fed proximal‐tubule‐select insulin receptor (IR), insulin‐like‐growth factor receptor (IGF1R) double knockout mice
por: Li, Lijun, et al.
Publicado: (2016)

Selective Deletion of the Mechanistic Target of Rapamycin From the Renal Collecting Duct Principal Cell in Mice Down-Regulates the Epithelial Sodium Channel
por: Chen, Bruce, et al.
Publicado: (2022)

Sex Modulates Response to Renal-Tubule-Targeted Insulin Receptor Deletion in Mice
por: Sohail, Soha, et al.
Publicado: (2023)

The Effect of Chronic Candesartan Therapy on the Metabolic Profile and Renal Tissue Cytokine Levels in the Obese Zucker Rat
por: Ecelbarger, Carolyn M., et al.
Publicado: (2010)

Liver or kidney: Who has the oar in the gluconeogenesis boat and when?
por: Sahoo, Biswajit, et al.
Publicado: (2023)

Urinary Exosomal microRNA-451-5p Is a Potential Early Biomarker of Diabetic Nephropathy in Rats
por: Mohan, Aradhana, et al.
Publicado: (2016)

Greater efficacy of atorvastatin versus a non-statin lipid-lowering agent against renal injury: potential role as a histone deacetylase inhibitor
por: Singh, Ravi Shankar, et al.
Publicado: (2016)

Effects of Chronic PPAR-Agonist Treatment on Cardiac Structure and Function, Blood Pressure, and Kidney in Healthy Sprague-Dawley Rats
por: Blasi, Eileen R., et al.
Publicado: (2009)

Corrigendum: miR-451 Loaded Exosomes Are Released by the Renal Cells in Response to Injury and Associated With Reduced Kidney Function in Human
por: Kumari, Manju, et al.
Publicado: (2020)

miR-451 Loaded Exosomes Are Released by the Renal Cells in Response to Injury and Associated With Reduced Kidney Function in Human
por: Kumari, Manju, et al.
Publicado: (2020)

Adjuvant Immunotherapy Is Dependent on Inducible Nitric Oxide Synthase
por: Kahn, Daniel A., et al.
Publicado: (2001)

Acute nitric oxide synthase inhibition induces greater increases in blood pressure in female versus male Wistar Kyoto rats
por: Elmarakby, Ahmed A., et al.
Publicado: (2023)

Endothelial nitric oxide synthase deficiency and inducible nitric oxide synthase inhibition in the setting of septic cardiomyopathy
por: Sandt, A Van de, et al.
Publicado: (2009)

Role of Polymorphisms of Inducible Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase in Idiopathic Environmental Intolerances
por: De Luca, Chiara, et al.
Publicado: (2015)

Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase
por: Serracino-Inglott, Ferdinand, et al.
Publicado: (2002)

Depletion of Cd4(+) T Cells Causes Reactivation of Murine Persistent Tuberculosis despite Continued Expression of Interferon γ and Nitric Oxide Synthase 2
por: Scanga, Charles A., et al.
Publicado: (2000)

Nitric Oxide Synthases and Atrial Fibrillation
por: Bonilla, Ingrid M., et al.
Publicado: (2012)

Nitric Oxide Synthase Inhibitors as Antidepressants
por: Wegener, Gregers, et al.
Publicado: (2010)

Nitric Oxide Synthases in Rheumatoid Arthritis
por: Huang, Jia-Bao, et al.
Publicado: (2023)

A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage
por: Gokay, Nevzat Selim, et al.
Publicado: (2016)

Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxide
por: Kopincová, Jana, et al.
Publicado: (2011)

Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase
por: Iwakiri, Yasuko
Publicado: (2015)

Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism
por: Tenopoulou, Margarita, et al.
Publicado: (2020)

Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates
por: Locascio, Annamaria, et al.
Publicado: (2023)

Down-Regulation of Protein Kinase Cδ Inhibits Inducible Nitric Oxide Synthase Expression through IRF1
por: Leppänen, Tiina, et al.
Publicado: (2013)

Diabetic Kidney Disease Represents a Locus of Opportunity
por: Ecelbarger, Carolyn Mary
Publicado: (2021)

Effects of inducible nitric oxide synthase and neuronal nitric oxide synthase inhibition on methicillin-resistant Staphylococcus aureus sepsis
por: Bansal, Kamna, et al.
Publicado: (2008)

Modulation of nitric oxide synthase activity in macrophages
por: Jorens, P. G., et al.
Publicado: (1995)

Suppression of arthritis by an inhibitor of nitric oxide synthase
Publicado: (1993)

Expression of nitric oxide synthase in nasal polyps
por: Yoshimura, Tsuyoshi, et al.
Publicado: (2010)

Alterations in Nitric Oxide Synthase in the Aged CNS
por: Jung, Junyang, et al.
Publicado: (2012)

Energy Landscapes and Catalysis in Nitric-oxide Synthase
por: Sobolewska-Stawiarz, Anna, et al.
Publicado: (2014)

Nitric oxide synthase and polycystic kidney disease
por: Wiwanitkit, Viroj
Publicado: (2015)

Neuronal nitric oxide synthase in hypertension – an update
por: Zhang, Yin Hua
Publicado: (2016)

Neuronal nitric oxide synthase and affective disorders
por: Zhou, Qi-Gang, et al.
Publicado: (2018)

Regulation of boar sperm functionality by the nitric oxide synthase/nitric oxide system
por: Staicu, Florentin-Daniel, et al.
Publicado: (2019)

Nitric oxide signalling and neuronal nitric oxide synthase in the heart under stress
por: Zhang, Yin Hua
Publicado: (2017)

Nitric oxide and inducible nitric oxide synthase levels in EE and NERD patients
por: Nejat PishKenari, Fatemeh, et al.
Publicado: (2022)

Nitric Oxide/Nitric Oxide Synthase System in the Pathogenesis of Neurodegenerative Disorders—An Overview
por: Iova, Olga-Maria, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_t9nuem8l4iimmcghgjs932s3l1