Design, Synthesis, and Cytotoxic Analysis of Novel Hederagenin–Pyrazine Derivatives Based on Partial Least Squares Discriminant Analysis

Hederagenin (He) is a novel triterpene template for the development of new antitumor compounds. In this study, 26 new He–pyrazine derivatives were synthetized in an attempt to develop potent antitumor agents; they were screened for in vitro cytotoxicity against tumor and non-tumor cell lines. The ma...

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Detalles Bibliográficos
Autores principales: Fang, Kang, Zhang, Xiao-Hua, Han, Yao-Tian, Wu, Gao-Rong, Cai, De-Sheng, Xue, Nan-Nan, Guo, Wen-Bo, Yang, Yu-Qin, Chen, Meng, Zhang, Xin-Yu, Wang, Hui, Ma, Tao, Wang, Peng-Long, Lei, Hai-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213900/
https://www.ncbi.nlm.nih.gov/pubmed/30274380
http://dx.doi.org/10.3390/ijms19102994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213900/
https://www.ncbi.nlm.nih.gov/pubmed/30274380
http://dx.doi.org/10.3390/ijms19102994

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