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A High-Content Screening Assay for the Discovery of Novel Proteasome Inhibitors from Formosan Soft Corals
The ubiquitin-proteasome system (UPS) is a major proteolytic pathway that safeguards protein homeostasis. The main 26S proteasome consists of a 20S catalytic core proteasome and a 19S substrate recognition proteasome. UPS dysfunction underlies many important clinical diseases involving inflammation,...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213913/ https://www.ncbi.nlm.nih.gov/pubmed/30347865 http://dx.doi.org/10.3390/md16100395 |