Optimized Expression and Characterization of a Novel Fully Human Bispecific Single-Chain Diabody Targeting Vascular Endothelial Growth Factor165 and Programmed Death-1 in Pichia pastoris and Evaluation of Antitumor Activity In Vivo

Bispecific antibodies, which can bind to two different epitopes on the same or different antigens simultaneously, have recently emerged as attractive candidates for study in various diseases. Our present study successfully constructs and expresses a fully human, bispecific, single-chain diabody (BsD...

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Detalles Bibliográficos
Autores principales: Xiong, Chenghao, Mao, Yingqing, Wu, Tao, Kang, Nannan, Zhao, Mingjun, Di, Rongrong, Li, Xiaoping, Ji, Xuemei, Liu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213929/
https://www.ncbi.nlm.nih.gov/pubmed/30257416
http://dx.doi.org/10.3390/ijms19102900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213929/
https://www.ncbi.nlm.nih.gov/pubmed/30257416
http://dx.doi.org/10.3390/ijms19102900

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