Cargando…

Novel Potentials of the DPP-4 Inhibitor Sitagliptin against Ischemia-Reperfusion (I/R) Injury in Rat Ex-Vivo Heart Model

Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of oral anti-diabetic drugs, implicated in pleiotropic secondary cardioprotective effects. The aim of the study was to unveil the unknown and possible cardioprotective targets that can be exerted by sitagliptin (Sitg) against ischemia-reperfusion...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-awar, Amin, Almási, Nikoletta, Szabó, Renáta, Takacs, Istvan, Murlasits, Zsolt, Szűcs, Gergő, Török, Szilvia, Pósa, Anikó, Varga, Csaba, Kupai, Krisztina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213995/ https://www.ncbi.nlm.nih.gov/pubmed/30340421 http://dx.doi.org/10.3390/ijms19103226

Ejemplares similares

Experimental Diabetes Mellitus in Different Animal Models
por: Al-awar, Amin, et al.
Publicado: (2016)

Sigma-1 Receptor Engages an Anti-Inflammatory and Antioxidant Feedback Loop Mediated by Peroxiredoxin in Experimental Colitis
por: Almási, Nikoletta, et al.
Publicado: (2020)

Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis: Modulation of the UCHL-1, IL-6 Pathway
por: Almási, Nikoletta, et al.
Publicado: (2020)

Investigation of H(2)S Donor Treatment on Neutrophil Extracellular Traps in Experimental Colitis
por: Török, Szilvia, et al.
Publicado: (2021)

Role of Exercise-Induced Cardiac Remodeling in Ovariectomized Female Rats
por: Szabó, Renáta, et al.
Publicado: (2018)

Consequences of exercising on ischemia–reperfusion injury in type 2 diabetic Goto-Kakizaki rat hearts: role of the HO/NOS system
por: Kupai, Krisztina, et al.
Publicado: (2015)

Exercise Training and Calorie Restriction Influence the Metabolic Parameters in Ovariectomized Female Rats
por: Pósa, Anikó, et al.
Publicado: (2015)

Voluntary Exercise-Mediated Protection in TNBS-Induced Rat Colitis: The Involvement of NETosis and Prdx Antioxidants
por: Almási, Nikoletta, et al.
Publicado: (2023)

Cardioprotective Effect of Selective Estrogen Receptor Modulator Raloxifene Are Mediated by Heme Oxygenase in Estrogen-Deficient Rat
por: Posa, Anikó, et al.
Publicado: (2017)

A Potential Involvement of Anandamide in the Modulation of HO/NOS Systems: Women, Menopause, and “Medical Cannabinoids”
por: Szabó, Renáta, et al.
Publicado: (2020)

Anti-Inflammatory Effect of Recreational Exercise in TNBS-Induced Colitis in Rats: Role of NOS/HO/MPO System
por: Szalai, Zita, et al.
Publicado: (2014)

Distinct Approaches of Raloxifene: Its Far-Reaching Beneficial Effects Implicating the HO-System
por: Börzsei, Denise, et al.
Publicado: (2020)

Protective Effects of H(2)S Donor Treatment in Experimental Colitis: A Focus on Antioxidants
por: Török, Szilvia, et al.
Publicado: (2023)

Spotlight on a New Heme Oxygenase Pathway: Testosterone-Induced Shifts in Cardiac Oxidant/Antioxidant Status
por: Szabó, Renáta, et al.
Publicado: (2019)

Role of physical activity and cardiorespiratory fitness in metabolically healthy obesity: a narrative review
por: Murlasits, Zsolt, et al.
Publicado: (2022)

Paclitaxel Protects against Isoproterenol-Induced Damage in Rat Myocardium: Its Heme-Oxygenase Mediated Role in Cardiovascular Research
por: Matusovits, Danica, et al.
Publicado: (2023)

Hormone Replacement Therapy and Aging: A Potential Therapeutic Approach for Age-Related Oxidative Stress and Cardiac Remodeling
por: Szabó, Renáta, et al.
Publicado: (2021)

Cardioprotective Effects of Voluntary Exercise in a Rat Model: Role of Matrix Metalloproteinase-2
por: Pósa, Anikó, et al.
Publicado: (2015)

Sexual Dimorphism of Cardiovascular Ischemia Susceptibility Is Mediated by Heme Oxygenase
por: Pósa, Anikó, et al.
Publicado: (2013)

The Interplay of Lifestyle and Adipokines in the Non-Obese Stroke-Prone Spontaneously Hypertensive Rats
por: Szabó, Renáta, et al.
Publicado: (2023)

Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause
por: Pósa, Anikó, et al.
Publicado: (2015)

Recent Progress in the Diagnosis and Management of Type 2 Diabetes Mellitus in the Era of COVID-19 and Single Cell Multi-Omics Technologies
por: Kupai, Krisztina, et al.
Publicado: (2022)

Potential Implications of Rimonabant on Age-Related Oxidative Stress and Inflammation
por: Szabó, Renáta, et al.
Publicado: (2022)

Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference
por: Sárközy, Márta, et al.
Publicado: (2014)

Use of DPP-4 inhibitors in type 2 diabetes: focus on sitagliptin
por: Ahrén, Bo
Publicado: (2010)

Dietary red palm oil supplementation decreases infarct size in cholesterol fed rats
por: Szucs, Gergo, et al.
Publicado: (2011)

Andrological Aspects of Exercise: Moderate Swimming Protects against Isoproterenol Induced Testis and Semen Abnormalities in Rats
por: Osváth, Péter, et al.
Publicado: (2022)

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve
por: Radak, Zsolt, et al.
Publicado: (2017)

New Metabolic Influencer on Oxytocin Release: The Ghrelin
por: Szabó, Renáta, et al.
Publicado: (2019)

Effect of Eccentric Exercise on Metabolic Health in Diabetes and Obesity
por: Szűcs, Gergő, et al.
Publicado: (2023)

Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes
por: Koyani, Chintan N., et al.
Publicado: (2018)

Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection
por: Bencsik, Péter, et al.
Publicado: (2018)

Sitagliptin, a DPP-4 Inhibitor, Acutely Inhibits Intestinal Lipoprotein Particle Secretion in Healthy Humans
por: Xiao, Changting, et al.
Publicado: (2014)

Peripheral blood and bronchoalveolar leukocyte profile in lung transplant recipients and their changes according to immunosuppressive regimen: A single‐center experience
por: Jáky‐Kováts, Zsuzsanna, et al.
Publicado: (2022)

Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells
por: Yoon, Hyunyee, et al.
Publicado: (2021)

Conserved and Distinct Elements of Phagocytosis in Human and C. elegans
por: Lukácsi, Szilvia, et al.
Publicado: (2021)

Heart Rate and Heart Rate Variability of Amateur Show Jumping Horses Competing on Different Levels
por: Szabó, Csaba, et al.
Publicado: (2021)

DPP4 Inhibitor Sitagliptin Enhances Lymphocyte Recruitment and Prolongs Survival in a Syngeneic Ovarian Cancer Mouse Model
por: Wilson, Amy L., et al.
Publicado: (2021)

Identification of DPP4/CTNNB1/MET as a Theranostic Signature of Thyroid Cancer and Evaluation of the Therapeutic Potential of Sitagliptin
por: Cheng, Sheng-Yao, et al.
Publicado: (2022)

All-Trans Retinoic Acid Enhances both the Signaling for Priming and the Glycolysis for Activation of NLRP3 Inflammasome in Human Macrophage
por: Alatshan, Ahmad, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_427b4bjjl4fd4ghdkqfjf0nbsa