Cargando…

The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells

Chemoresistance is a major limiting factor that impairs the outcome of non-small cell lung cancer (NSCLC) chemotherapy. Paclitaxel (Tax) induces protective autophagy in NSCLC cells, leading to the development of drug resistance. We recently identified a new autophagy inhibitor (alpha-hederin) and hy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhan, Yujuan, Wang, Kun, Li, Qiao, Zou, Yidan, Chen, Bonan, Gong, Qing, HO, Hiuting Idy, Yin, Ting, Zhang, Fangyuan, Lu, Yuhua, Wu, Weijie, Zhang, Yilin, Tan, Yuhui, Du, Biaoyan, Liu, Xiaodong, Xiao, Jianyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214018/ https://www.ncbi.nlm.nih.gov/pubmed/30340379 http://dx.doi.org/10.3390/ijms19103221

Ejemplares similares

N-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells
por: Wang, Kun, et al.
Publicado: (2019)

Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells
por: Wang, Kun, et al.
Publicado: (2020)

Blockage of Autophagic Flux and Induction of Mitochondria Fragmentation by Paroxetine Hydrochloride in Lung Cancer Cells Promotes Apoptosis via the ROS-MAPK Pathway
por: Wang, Kun, et al.
Publicado: (2020)

Synthesis and Tumor Cytotoxicity of Novel Amide Derivatives of β-Hederin
por: Liu, Yang, et al.
Publicado: (2010)

Tubeimoside I-induced lung cancer cell death and the underlying crosstalk between lysosomes and mitochondria
por: Wang, Kun, et al.
Publicado: (2020)

Aleuritolic Acid Impaired Autophagic Flux and Induced Apoptosis in Hepatocellular Carcinoma HepG2 Cells
por: Yi, Hua, et al.
Publicado: (2018)

AICD: an integrated anti-inflammatory compounds database for drug discovery
por: Wang, Kun, et al.
Publicado: (2019)

Alpha-Hederin, the Active Saponin of Nigella sativa, as an Anticancer Agent Inducing Apoptosis in the SKOV-3 Cell Line
por: Adamska, Anna, et al.
Publicado: (2019)

miR-34b inhibits nasopharyngeal carcinoma cell proliferation by targeting ubiquitin-specific peptidase 22
por: Xiao, Jianyong, et al.
Publicado: (2016)

Mitochondrial pathway mediated by reactive oxygen species involvement in α-hederin-induced apoptosis in hepatocellular carcinoma cells
por: Li, Jiao, et al.
Publicado: (2018)

d Rhamnose β-hederin reverses chemoresistance of breast cancer cells by regulating exosome-mediated resistance transmission
por: Chen, Wei-xian, et al.
Publicado: (2018)

α-Hederin Increases The Apoptosis Of Cisplatin-Resistant Gastric Cancer Cells By Activating Mitochondrial Pathway In Vivo And Vitro
por: Liu, Yinghui, et al.
Publicado: (2019)

α-Hederin Inhibits the Proliferation of Hepatocellular Carcinoma Cells via Hippo-Yes-Associated Protein Signaling Pathway
por: Chen, Tongqing, et al.
Publicado: (2022)

α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis
por: Fang, Cong, et al.
Publicado: (2020)

Synergistic effect of resveratrol and HSV-TK/GCV therapy on murine hepatoma cells
por: Xiao, Jianyong, et al.
Publicado: (2018)

The Apoptotic Effect of D Rhamnose β-Hederin, a Novel Oleanane-Type Triterpenoid Saponin on Breast Cancer Cells
por: Cheng, Lin, et al.
Publicado: (2014)

D Rhamnose β-Hederin against human breast cancer by reducing tumor-derived exosomes
por: Chen, Wei-Xian, et al.
Publicado: (2018)

α-Hederin regulates macrophage polarization to relieve sepsis-induced lung and liver injuries in mice
por: Zeng, Junan, et al.
Publicado: (2023)

CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells
por: Zhu, Rong, et al.
Publicado: (2015)

α-hederin overcomes hypoxia-mediated drug resistance in colorectal cancer by inhibiting the AKT/Bcl2 pathway
por: Chen, Jinbao, et al.
Publicado: (2023)

α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation
por: Sun, Jian, et al.
Publicado: (2019)

α-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-κB Signaling in Colon Cancer Cells
por: Sun, Dongdong, et al.
Publicado: (2018)

Dioscin augments HSV-tk-mediated suicide gene therapy for melanoma by promoting connexin-based intercellular communication
por: Xiao, Jianyong, et al.
Publicado: (2016)

Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbumin-sensitized male rats
por: Fallahi, Maryam, et al.
Publicado: (2016)

Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines.
por: Liebmann, J. E., et al.
Publicado: (1993)

Clinical Characteristics, Treatment Effectiveness, and Predictors of Response to Pharmacotherapeutic Interventions Among Patients with Herpetic-Related Neuralgia: A Retrospective Analysis
por: Zhou, Jiehua, et al.
Publicado: (2021)

Molecular Mechanism for Selective Cytotoxicity towards Cancer Cells of Diselenide-Containing Paclitaxel Nanoparticles
por: Li, Jing, et al.
Publicado: (2019)

Cancer Cell enters reversible quiescence through Intracellular Acidification to resist Paclitaxel Cytotoxicity
por: Jia, Min, et al.
Publicado: (2020)

Tanshinone IIA Increases the Bystander Effect of Herpes Simplex Virus Thymidine Kinase/Ganciclovir Gene Therapy via Enhanced Gap Junctional Intercellular Communication
por: Xiao, Jianyong, et al.
Publicado: (2013)

Enhancing Effects of Curcumin on Cytotoxicity of Paclitaxel, Methotrexate and Vincristine in Gastric Cancer Cells
por: Ebrahimifar, Meysam, et al.
Publicado: (2017)

PEGylated Paclitaxel Nanomedicine Meets 3D Confinement: Cytotoxicity and Cell Behaviors
por: Lin, Wenhai, et al.
Publicado: (2023)

The Interface amongst Conserved and Specialized Pathways in Non-Paclitaxel and Paclitaxel Accumulating Taxus Cultures
por: McKee, Michelle C., et al.
Publicado: (2021)

Blockade of Autophagy Aggravates Endoplasmic Reticulum Stress and Improves Paclitaxel Cytotoxicity in Human Cervical Cancer Cells
por: Xu, Li, et al.
Publicado: (2015)

Potentiation of Paclitaxel Cytotoxicity by Inostamycin in Human Small Cell Lung Carcinoma, Ms‐1 Cells
por: Simizu, Siro, et al.
Publicado: (1998)

Paclitaxel loading in PLGA nanospheres affected the in vitro drug cell accumulation and antiproliferative activity
por: Vicari, Luisa, et al.
Publicado: (2008)

Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation
por: Zhou, Xiang, et al.
Publicado: (2015)

Elevated Adenylyl Cyclase 9 Expression Is a Potential Prognostic Biomarker for Patients with Colon Cancer
por: Yi, Hua, et al.
Publicado: (2018)

Mesenchymal stromal cells loaded with paclitaxel induce cytotoxic damage in glioblastoma brain xenografts
por: Pacioni, Simone, et al.
Publicado: (2015)

Exposure to low intensity ultrasound removes paclitaxel cytotoxicity in breast and ovarian cancer cells
por: Amaya, Celina, et al.
Publicado: (2021)

Overexpression of Rho-Associated Coiled-Coil Containing Protein Kinase 2 Is Correlated with Clinical Progression and Poor Prognosis in Breast Cancer
por: Yi, Hua, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_kg5d7bqjmfpapus17b6bdcs7r1