The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma

The family of cyclin-dependent kinases (CDKs) has critical functions in cell cycle regulation and controlling of transcriptional elongation. Moreover, dysregulated CDKs have been linked to cancer initiation and progression. Pharmacological CDK inhibition has recently emerged as a novel and promising...

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Autores principales: García-Reyes, Balbina, Kretz, Anna-Laura, Ruff, Jan-Philipp, von Karstedt, Silvia, Hillenbrand, Andreas, Knippschild, Uwe, Henne-Bruns, Doris, Lemke, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214075/
https://www.ncbi.nlm.nih.gov/pubmed/30340359
http://dx.doi.org/10.3390/ijms19103219
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author García-Reyes, Balbina
Kretz, Anna-Laura
Ruff, Jan-Philipp
von Karstedt, Silvia
Hillenbrand, Andreas
Knippschild, Uwe
Henne-Bruns, Doris
Lemke, Johannes
author_facet García-Reyes, Balbina
Kretz, Anna-Laura
Ruff, Jan-Philipp
von Karstedt, Silvia
Hillenbrand, Andreas
Knippschild, Uwe
Henne-Bruns, Doris
Lemke, Johannes
author_sort García-Reyes, Balbina
collection PubMed
description The family of cyclin-dependent kinases (CDKs) has critical functions in cell cycle regulation and controlling of transcriptional elongation. Moreover, dysregulated CDKs have been linked to cancer initiation and progression. Pharmacological CDK inhibition has recently emerged as a novel and promising approach in cancer therapy. This idea is of particular interest to combat pancreatic ductal adenocarcinoma (PDAC), a cancer entity with a dismal prognosis which is owed mainly to PDAC’s resistance to conventional therapies. Here, we review the current knowledge of CDK biology, its role in cancer and the therapeutic potential to target CDKs as a novel treatment strategy for PDAC.
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spelling pubmed-62140752018-11-14 The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma García-Reyes, Balbina Kretz, Anna-Laura Ruff, Jan-Philipp von Karstedt, Silvia Hillenbrand, Andreas Knippschild, Uwe Henne-Bruns, Doris Lemke, Johannes Int J Mol Sci Review The family of cyclin-dependent kinases (CDKs) has critical functions in cell cycle regulation and controlling of transcriptional elongation. Moreover, dysregulated CDKs have been linked to cancer initiation and progression. Pharmacological CDK inhibition has recently emerged as a novel and promising approach in cancer therapy. This idea is of particular interest to combat pancreatic ductal adenocarcinoma (PDAC), a cancer entity with a dismal prognosis which is owed mainly to PDAC’s resistance to conventional therapies. Here, we review the current knowledge of CDK biology, its role in cancer and the therapeutic potential to target CDKs as a novel treatment strategy for PDAC. MDPI 2018-10-18 /pmc/articles/PMC6214075/ /pubmed/30340359 http://dx.doi.org/10.3390/ijms19103219 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
García-Reyes, Balbina
Kretz, Anna-Laura
Ruff, Jan-Philipp
von Karstedt, Silvia
Hillenbrand, Andreas
Knippschild, Uwe
Henne-Bruns, Doris
Lemke, Johannes
The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma
title The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma
title_full The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma
title_fullStr The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma
title_full_unstemmed The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma
title_short The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma
title_sort emerging role of cyclin-dependent kinases (cdks) in pancreatic ductal adenocarcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214075/
https://www.ncbi.nlm.nih.gov/pubmed/30340359
http://dx.doi.org/10.3390/ijms19103219
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