Synthesis and In Vitro Antitumor Activity of Novel Bivalent β-Carboline-3-carboxylic Acid Derivatives with DNA as a Potential Target

A series of novel bivalent β-carboline derivatives were designed and synthesized, and in vitro cytotoxicity, cell apoptosis, and DNA-binding affinity were evaluated. The cytotoxic results demonstrated that most bivalent β-carboline derivatives exhibited stronger cytotoxicity than the corresponding m...

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Detalles Bibliográficos
Autores principales: Gu, Hongling, Li, Na, Dai, Jiangkun, Xi, Yaxi, Wang, Shijun, Wang, Junru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214108/
https://www.ncbi.nlm.nih.gov/pubmed/30326662
http://dx.doi.org/10.3390/ijms19103179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214108/
https://www.ncbi.nlm.nih.gov/pubmed/30326662
http://dx.doi.org/10.3390/ijms19103179

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