Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis

Liver dysfunction during sepsis is an independent risk factor leading to increased mortality rates. Specifically, dysregulation of hepatic biotransformation capacity, especially of the cytochrome P450 (CYP) system, represents an important distress factor during host response. The activity of the con...

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Detalles Bibliográficos
Autores principales: Chung, Ha-Yeun, Witt, C. Julius, Hurtado-Oliveros, Jorge, Wickel, Jonathan, Gräler, Markus H., Lupp, Amelie, Claus, Ralf A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214114/
https://www.ncbi.nlm.nih.gov/pubmed/30326559
http://dx.doi.org/10.3390/ijms19103163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214114/
https://www.ncbi.nlm.nih.gov/pubmed/30326559
http://dx.doi.org/10.3390/ijms19103163

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