Atrial Fibrillation Initiated by Early Afterdepolarization-Mediated Triggered Activity during Acute Oxidative Stress: Efficacy of Late Sodium Current Blockade

BACKGROUND: The mechanism of Atrial Fibrillation (AF) that emerges spontaneously during acute oxidative stress is poorly defined and its drug therapy remains suboptimal. We hypothesized that oxidative activation of Ca-calmodulin dependent protein kinase (CaMKII) promotes Early Afterdepolarization-(E...

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Detalles Bibliográficos
Autores principales: Pezhouman, Arash, Cao, Hong, Fishbein, Michael C, Belardinelli, Luiz, Weiss, James N, Karagueuzian, Hrayr S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214459/
https://www.ncbi.nlm.nih.gov/pubmed/30393761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214459/
https://www.ncbi.nlm.nih.gov/pubmed/30393761

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