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Atrial Fibrillation Initiated by Early Afterdepolarization-Mediated Triggered Activity during Acute Oxidative Stress: Efficacy of Late Sodium Current Blockade

BACKGROUND: The mechanism of Atrial Fibrillation (AF) that emerges spontaneously during acute oxidative stress is poorly defined and its drug therapy remains suboptimal. We hypothesized that oxidative activation of Ca-calmodulin dependent protein kinase (CaMKII) promotes Early Afterdepolarization-(E...

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Detalles Bibliográficos
Autores principales:	Pezhouman, Arash, Cao, Hong, Fishbein, Michael C, Belardinelli, Luiz, Weiss, James N, Karagueuzian, Hrayr S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214459/ https://www.ncbi.nlm.nih.gov/pubmed/30393761

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