Methylation dependent down-regulation of G0S2 leads to suppression of invasion and improved prognosis of IDH1-mutant glioma

Isocitrate dehydrogenase (IDH) mutations are a prognostic factor in diffuse glioma. However, the mechanism by which these mutations improve prognosis are not clear. In a subset of IDH-mutant glioma, remodeling of the methylome results in the glioma-CpG island methylator phenotype (G-CIMP) and transc...

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Detalles Bibliográficos
Autores principales: Fukunaga, Takanori, Fujita, Yuki, Kishima, Haruhiko, Yamashita, Toshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214530/
https://www.ncbi.nlm.nih.gov/pubmed/30388142
http://dx.doi.org/10.1371/journal.pone.0206552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214530/
https://www.ncbi.nlm.nih.gov/pubmed/30388142
http://dx.doi.org/10.1371/journal.pone.0206552

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