OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

TET enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine and higher oxidized derivatives. TETs stably associate with and are post-translationally modified by the nutrient-sensing enzyme OGT, suggesting a connection between metabolism and the epigenome. Here, we show for the first time that mo...

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Detalles Bibliográficos
Autores principales: Hrit, Joel, Goodrich, Leeanne, Li, Cheng, Wang, Bang-An, Nie, Ji, Cui, Xiaolong, Martin, Elizabeth Allene, Simental, Eric, Fernandez, Jenna, Liu, Monica Yun, Nery, Joseph R, Castanon, Rosa, Kohli, Rahul M, Tretyakova, Natalia, He, Chuan, Ecker, Joseph R, Goll, Mary, Panning, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214653/
https://www.ncbi.nlm.nih.gov/pubmed/30325306
http://dx.doi.org/10.7554/eLife.34870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214653/
https://www.ncbi.nlm.nih.gov/pubmed/30325306
http://dx.doi.org/10.7554/eLife.34870

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