Cargando…

An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2

α-N-terminal methylation of proteins is an important post-translational modification that is catalyzed by two different N-terminal methyltransferases, namely NTMT1 and NTMT2. Previous studies have suggested that NTMT1 is a tri-methyltransferase, whereas NTMT2 is a mono-methyltransferase. Here, we re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Cheng, Dong, Guangping, Li, Li, Zhu, Licheng, Tempel, Wolfram, Liu, Yanli, Huang, Rong, Min, Jinrong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214909/ https://www.ncbi.nlm.nih.gov/pubmed/30417120 http://dx.doi.org/10.1038/s42003-018-0196-2

Ejemplares similares

Structural basis for substrate recognition by the human N-terminal methyltransferase 1
por: Dong, Cheng, et al.
Publicado: (2015)

In vivo methylation of OLA1 revealed by activity-based target profiling of NTMT1
por: Jia, Kaimin, et al.
Publicado: (2019)

Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1
por: Dong, Guangping, et al.
Publicado: (2022)

Characterization of N-Terminal Asparagine Deamidation and Clipping of a Monoclonal Antibody
por: Zhen, Jing, et al.
Publicado: (2023)

THE CONDUCTIVITIES OF AQUEOUS SOLUTIONS OF GLYCINE, d,l-VALINE, AND l-ASPARAGINE
por: Mehl, John W., et al.
Publicado: (1935)

Chemical Biology of Protein N‐Terminal Methyltransferases
por: Huang, Rong
Publicado: (2019)

Convergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase
por: Zhang, Jianyu, et al.
Publicado: (2016)

Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase
por: Simile, Maria M., et al.
Publicado: (2021)

Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells
por: Ottaviani, Silvia, et al.
Publicado: (2013)

Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
por: Lee, Yi-Ru, et al.
Publicado: (2016)

Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate
por: Schuhmacher, Maren Kirstin, et al.
Publicado: (2020)

N-(Phenylsulfonyl)-l-asparagine
por: Arshad, Muhammad Nadeem, et al.
Publicado: (2009)

Author Correction: Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate
por: Schuhmacher, Maren Kirstin, et al.
Publicado: (2020)

Improvement of the glycoproteomic toolbox with the discovery of a unique C-terminal cleavage specificity of flavastacin for N-glycosylated asparagine
por: Pralow, Alexander, et al.
Publicado: (2017)

Alterations of methionine metabolism in hepatocarcinogenesis: the emergent role of glycine N-methyltransferase in liver injury
por: Simile, Maria M., et al.
Publicado: (2018)

PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
por: Zabala-Letona, Amaia, et al.
Publicado: (2022)

Thermal decomposition of the amino acids glycine, cysteine, aspartic acid, asparagine, glutamic acid, glutamine, arginine and histidine
por: Weiss, Ingrid M., et al.
Publicado: (2018)

MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma
por: Hung, Jung-Hsien, et al.
Publicado: (2018)

Human G protein-coupled receptor 30 is N-glycosylated and N-terminal domain asparagine 44 is required for receptor structure and activity
por: Gonzalez de Valdivia, Ernesto, et al.
Publicado: (2019)

N-(p-Tolylsulfonyl)-l-asparagine
por: Arshad, Muhammad Nadeem, et al.
Publicado: (2010)

Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production
por: Tain, Luke S., et al.
Publicado: (2019)

Folic Acid Ameliorates Renal Injury in Experimental Obstructive Nephropathy: Role of Glycine N-Methyltransferase
por: Kuo, Ko-Lin, et al.
Publicado: (2023)

Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine
por: Loureiro, Inês, et al.
Publicado: (2013)

Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome
por: Wu, Hong, et al.
Publicado: (2015)

Cloning and Functional Identification of Phosphoethanolamine Methyltransferase in Soybean (Glycine max)
por: Ji, Xiaomin, et al.
Publicado: (2021)

Polymorphism in asparagine synthetase is associated with overall survival of hepatocellular carcinoma patients
por: Li, Wei, et al.
Publicado: (2017)

Genetic Polymorphisms of the Glycine N-Methyltransferase and Prostate Cancer Risk in the Health Professionals Follow-Up Study
por: Chen, Marcelo, et al.
Publicado: (2014)

Androgen response element of the glycine N-methyltransferase gene is located in the coding region of its first exon
por: Lee, Cheng-Ming, et al.
Publicado: (2013)

Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction
por: Rome, Ferrol I., et al.
Publicado: (2022)

Correction: Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine
por: Loureiro, Inês, et al.
Publicado: (2013)

Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells
por: Chang, Mario C., et al.
Publicado: (2023)

Computational Analysis of the Mechanism of Nonenzymatic Peptide Bond Cleavage at the C-Terminal Side of an Asparagine Residue
por: Kato, Koichi, et al.
Publicado: (2021)

The comprehensive analysis of the prognostic and functional role of N-terminal methyltransferases 1 in pan-cancer
por: Tan, Lifan, et al.
Publicado: (2023)

Coordination of asparagine uptake and asparagine synthetase expression modulates CD8(+) T cell activation
por: Hope, Helen Carrasco, et al.
Publicado: (2021)

Analysis of Enzyme Activity and Cellular Function for the N80S and S480F Asparagine Synthetase Variants Expressed in a Child with Asparagine Synthetase Deficiency
por: Staklinski, Stephen J., et al.
Publicado: (2022)

Association of N-Acetyl Asparagine with QTc in Diabetes: A Metabolomics Study
por: Gravina, Giacomo, et al.
Publicado: (2022)

Cereal asparagine synthetase genes
por: Raffan, Sarah, et al.
Publicado: (2020)

Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5
por: Al-Hamashi, Ayad A., et al.
Publicado: (2021)

Synthesis of L-asparagine Catalyzed by a Novel Asparagine Synthase Coupled With an ATP Regeneration System
por: Luo, Wei, et al.
Publicado: (2021)

Understanding the Relationships between Free Asparagine in Grain and Other Traits to Breed Low-Asparagine Wheat
por: Oddy, Joseph, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h59c8idkihtdjd7jddjn1ktg6n