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An information-theoretic framework for deciphering pleiotropic and noisy biochemical signaling

Many components of signaling pathways are functionally pleiotropic, and signaling responses are marked with substantial cell-to-cell heterogeneity. Therefore, biochemical descriptions of signaling require quantitative support to explain how complex stimuli (inputs) are encoded in distinct activities...

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Detalles Bibliográficos
Autores principales: Jetka, Tomasz, Nienałtowski, Karol, Filippi, Sarah, Stumpf, Michael P. H., Komorowski, Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214929/
https://www.ncbi.nlm.nih.gov/pubmed/30389942
http://dx.doi.org/10.1038/s41467-018-07085-1