Cargando…

PMA inhibits endothelial cell migration through activating the PKC-δ/Syk/NF-κB-mediated up-regulation of Thy-1

We previously showed that overexpression of Thy-1 inhibited and knock-down of Thy-1 enhanced endothelial cell migration. Here, we used phorbol-12-myristate-13-acetate (PMA) as an inducer for Thy-1 expression to investigate molecular mechanisms underlying Thy-1 up-regulation. Our data showed that inc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wen, Heng-Ching, Huo, Yen Nien, Chou, Chih-Ming, Lee, Wen-Sen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214930/ https://www.ncbi.nlm.nih.gov/pubmed/30389973 http://dx.doi.org/10.1038/s41598-018-34548-8

Ejemplares similares

Thy-1-Induced Migration Inhibition in Vascular Endothelial Cells through Reducing the RhoA Activity
por: Wen, Heng-Ching, et al.
Publicado: (2013)

The FcγRIII Engagement Augments PMA-Stimulated Neutrophil Extracellular Traps (NETs) Formation by Granulocytes Partially via Cross-Talk between Syk-ERK-NF-κB and PKC-ROS Signaling Pathways
por: Lu, Cheng-Hsun, et al.
Publicado: (2021)

Perilla Leaf Extract (PLE) Attenuates COPD Airway Inflammation via the TLR4/Syk/PKC/NF-κB Pathway In Vivo and In Vitro
por: Yuan, Jiqiao, et al.
Publicado: (2022)

PKCδ Mediates NF-κB Inflammatory Response and Downregulates SIRT1 Expression in Liver Fibrosis
por: Lee, Su Jin, et al.
Publicado: (2019)

Activation of PKCβII by PMA Facilitates Enhanced Epithelial Wound Repair through Increased Cell Spreading and Migration
por: Sumagin, Ronen, et al.
Publicado: (2013)

Protein Kinase C δ (PKCδ) Attenuates Bleomycin Induced Pulmonary Fibrosis via Inhibiting NF-κB Signaling Pathway
por: Wang, Jun, et al.
Publicado: (2020)

PKCα and PKCδ: Friends and Rivals
por: Black, Jennifer D., et al.
Publicado: (2022)

PKC-Dependent Human Monocyte Adhesion Requires AMPK and Syk Activation
por: Chang, Mei-Ying, et al.
Publicado: (2012)

Identification of lipocalin-2 as a PKCδ phosphorylation substrate in neutrophils
por: Weng, Yi-Chinn, et al.
Publicado: (2015)

Suppression of PMA-induced tumor cell invasion and migration by ginsenoside Rg1 via the inhibition of NF-κB-dependent MMP-9 expression
por: LI, LI, et al.
Publicado: (2014)

Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer
por: Yueh, Po-Fu, et al.
Publicado: (2021)

PKCδ/MAPKs and NF-κB Pathways are Involved in the Regulation of Ingenane-Type Diterpenoids from Euphorbia neriifolia on Macrophage Function
por: Jiang, Mingyan, et al.
Publicado: (2021)

Syk-Mediated Translocation of PI3Kδ to the Leading Edge Controls Lamellipodium Formation and Migration of Leukocytes
por: Schymeinsky, Jürgen, et al.
Publicado: (2007)

Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets
por: Pears, Catherine J., et al.
Publicado: (2008)

PKCδ Blues for the β-Cell
por: Schmitz-Peiffer, Carsten, et al.
Publicado: (2010)

PKCδ promotes the invasion and migration of colorectal cancer through c-myc/NDRG1 pathway
por: Jia, Hong-tao, et al.
Publicado: (2023)

Suppression of PKCδ/NF-κB Signaling and Apoptosis Induction through Extrinsic/Intrinsic Pathways Are Associated with Magnolol-Inhibited Tumor Progression in Colorectal Cancer In Vitro and In Vivo
por: Su, Chun-Min, et al.
Publicado: (2020)

Genetic signature of human longevity in PKC and NF‐κB signaling
por: Ryu, Seungjin, et al.
Publicado: (2021)

Overexpressed PKCδ Downregulates the Expression of PKCα in B16F10 Melanoma: Induction of Apoptosis by PKCδ via Ceramide Generation
por: Halder, Kuntal, et al.
Publicado: (2014)

Enhanced PKCδ and ERK Signaling Mediate Cell Migration of Retinal Pigment Epithelial Cells Synergistically Induced by HGF and EGF
por: Chen, Yu Jung, et al.
Publicado: (2012)

Tulobuterol patch alleviates allergic asthmic inflammation by blockade of Syk and NF-κB activation in mice
por: Fu, Lixia, et al.
Publicado: (2018)

Anti-Inflammatory Effect of Meriania hexamera Sprague by Targeting Syk Kinase in NF-κB Signaling
por: Kwon, Ki Woong, et al.
Publicado: (2023)

Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages
por: Cao, Jiatian, et al.
Publicado: (2014)

Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation
por: Liu, Mengling, et al.
Publicado: (2017)

Pkcδ Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products (Ages)
por: Yang, Yao-Chih, et al.
Publicado: (2018)

PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs
por: Chen, Chia-Hung, et al.
Publicado: (2021)

PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production
por: Serrero, Manutea, et al.
Publicado: (2017)

PLCE1 Promotes the Invasion and Migration of Esophageal Cancer Cells by Up-Regulating the PKCα/NF-κB Pathway
por: Li, Yongzhu, et al.
Publicado: (2018)

Chondroprotective and anti‐inflammatory effects of amurensin H by regulating TLR4/Syk/NF‐κB signals
por: Ma, Pei, et al.
Publicado: (2019)

Role and mechanism of the Dectin-1-mediated Syk/NF-κB signaling pathway in Talaromyces marneffei infection
por: Peng, Yang, et al.
Publicado: (2022)

Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis
por: Li, Yuanjie, et al.
Publicado: (2021)

Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling
por: Wang, Jen-Jui, et al.
Publicado: (2012)

Construction and characterization of thymidine auxotrophic (ΔthyA) recombinant Lactobacillus casei expressing bovine lactoferricin
por: Zhou, Han, et al.
Publicado: (2018)

B7-H4 expression is upregulated by PKCδ activation and contributes to PKCδ-induced cell motility in colorectal cancer
por: Zhou, Bin, et al.
Publicado: (2022)

PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling
por: Hashimoto, Koji, et al.
Publicado: (2012)

Ranunculus bulumei Methanol Extract Exerts Anti-Inflammatory Activity by Targeting Src/Syk in NF-κB Signaling
por: Hong, Yo Han, et al.
Publicado: (2020)

PKCδ regulates the vascular biology in diabetic atherosclerosis
por: Qin, Peiliang, et al.
Publicado: (2023)

Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets
por: Zhang, Pengyu, et al.
Publicado: (2023)

PKCδ deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCδ knockout mice
por: Niino, Yuko S., et al.
Publicado: (2021)

Thrombomodulin regulates monocye differentiation via PKCδ and ERK1/2 pathway in vitro and in atherosclerotic artery
por: Tsai, Chien-Sung, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_b6l7au2qecpmd74c2qlrgmo5s5