Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity

Here we introduce Protein-indexed Assay of Transposase Accessible Chromatin with sequencing (Pi-ATAC) that combines single-cell chromatin and proteomic profiling. In conjunction with DNA transposition, the levels of multiple cell surface or intracellular protein epitopes are recorded by index flow c...

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Detalles Bibliográficos
Autores principales: Chen, Xingqi, Litzenburger, Ulrike M., Wei, Yuning, Schep, Alicia N., LaGory, Edward L., Choudhry, Hani, Giaccia, Amato J., Greenleaf, William J., Chang, Howard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214962/
https://www.ncbi.nlm.nih.gov/pubmed/30389926
http://dx.doi.org/10.1038/s41467-018-07115-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214962/
https://www.ncbi.nlm.nih.gov/pubmed/30389926
http://dx.doi.org/10.1038/s41467-018-07115-y

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