Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

The availability of multiple datasets comprising genome-scale RNAi viability screens in hundreds of diverse cancer cell lines presents new opportunities for understanding cancer vulnerabilities. Integrated analyses of these data to assess differential dependency across genes and cell lines are chall...

Descripción completa

Detalles Bibliográficos
Autores principales: McFarland, James M., Ho, Zandra V., Kugener, Guillaume, Dempster, Joshua M., Montgomery, Phillip G., Bryan, Jordan G., Krill-Burger, John M., Green, Thomas M., Vazquez, Francisca, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Tsherniak, Aviad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214982/
https://www.ncbi.nlm.nih.gov/pubmed/30389920
http://dx.doi.org/10.1038/s41467-018-06916-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214982/
https://www.ncbi.nlm.nih.gov/pubmed/30389920
http://dx.doi.org/10.1038/s41467-018-06916-5

Ejemplares similares