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Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer
Usnic acid (UA), a lichen secondary substance, has considerable anticancer activity in vitro, whereas its effect in vivo is limited. Here, potassium usnate (KU) was prepared by the salinization of UA to enhance its water solubility. KU showed increased bioavailability compared with UA in the tumor,...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214985/ https://www.ncbi.nlm.nih.gov/pubmed/30390003 http://dx.doi.org/10.1038/s41598-018-34709-9 |
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| author | Yang, Yi Bae, Woo Kyun Lee, Ji-Yoon Choi, Yong Jae Lee, Kyung Hwa Park, Myong-Suk Yu, Young Hyun Park, So-Yeon Zhou, Rui Taş, İsa Gamage, Chathurika Paik, Man-Jeong Lee, Jae Hyuk Chung, Ik Joo Kim, Kyung Keun Hur, Jae-Seoun Kim, Sang Kyum Ha, Hyung-Ho Kim, Hangun |
| author_facet | Yang, Yi Bae, Woo Kyun Lee, Ji-Yoon Choi, Yong Jae Lee, Kyung Hwa Park, Myong-Suk Yu, Young Hyun Park, So-Yeon Zhou, Rui Taş, İsa Gamage, Chathurika Paik, Man-Jeong Lee, Jae Hyuk Chung, Ik Joo Kim, Kyung Keun Hur, Jae-Seoun Kim, Sang Kyum Ha, Hyung-Ho Kim, Hangun |
| author_sort | Yang, Yi |
| collection | PubMed |
| description | Usnic acid (UA), a lichen secondary substance, has considerable anticancer activity in vitro, whereas its effect in vivo is limited. Here, potassium usnate (KU) was prepared by the salinization of UA to enhance its water solubility. KU showed increased bioavailability compared with UA in the tumor, liver, and plasma of a CT26 syngeneic mouse tumor xenograft model after oral administration, as determined by LC-MS/MS analysis. KU exhibited potent anticancer effects on colorectal cancer cells and inhibited liver metastasis in an orthotopic murine colorectal cancer model. KU treatment downregulated the epithelial-mesenchymal markers Twist, Snail, and Slug and the metastasis-related genes CAPN1, CDC42, CFL1, IGF1, WASF1, and WASL in cells and tumor tissues. The present results suggest the potential application of the water-soluble form of UA, KU, in anticancer therapy. |
| format | Online Article Text |
| id | pubmed-6214985 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62149852018-11-06 Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer Yang, Yi Bae, Woo Kyun Lee, Ji-Yoon Choi, Yong Jae Lee, Kyung Hwa Park, Myong-Suk Yu, Young Hyun Park, So-Yeon Zhou, Rui Taş, İsa Gamage, Chathurika Paik, Man-Jeong Lee, Jae Hyuk Chung, Ik Joo Kim, Kyung Keun Hur, Jae-Seoun Kim, Sang Kyum Ha, Hyung-Ho Kim, Hangun Sci Rep Article Usnic acid (UA), a lichen secondary substance, has considerable anticancer activity in vitro, whereas its effect in vivo is limited. Here, potassium usnate (KU) was prepared by the salinization of UA to enhance its water solubility. KU showed increased bioavailability compared with UA in the tumor, liver, and plasma of a CT26 syngeneic mouse tumor xenograft model after oral administration, as determined by LC-MS/MS analysis. KU exhibited potent anticancer effects on colorectal cancer cells and inhibited liver metastasis in an orthotopic murine colorectal cancer model. KU treatment downregulated the epithelial-mesenchymal markers Twist, Snail, and Slug and the metastasis-related genes CAPN1, CDC42, CFL1, IGF1, WASF1, and WASL in cells and tumor tissues. The present results suggest the potential application of the water-soluble form of UA, KU, in anticancer therapy. Nature Publishing Group UK 2018-11-02 /pmc/articles/PMC6214985/ /pubmed/30390003 http://dx.doi.org/10.1038/s41598-018-34709-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Yang, Yi Bae, Woo Kyun Lee, Ji-Yoon Choi, Yong Jae Lee, Kyung Hwa Park, Myong-Suk Yu, Young Hyun Park, So-Yeon Zhou, Rui Taş, İsa Gamage, Chathurika Paik, Man-Jeong Lee, Jae Hyuk Chung, Ik Joo Kim, Kyung Keun Hur, Jae-Seoun Kim, Sang Kyum Ha, Hyung-Ho Kim, Hangun Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer |
| title | Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer |
| title_full | Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer |
| title_fullStr | Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer |
| title_full_unstemmed | Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer |
| title_short | Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer |
| title_sort | potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214985/ https://www.ncbi.nlm.nih.gov/pubmed/30390003 http://dx.doi.org/10.1038/s41598-018-34709-9 |
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