Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis

Although additional sex combs-like 1 (ASXL1) has been extensively described in hematologic malignancies, little is known about the molecular role of ASXL1 in organ development. Here, we show that Asxl1 ablation in mice results in postnatal lethality due to cyanosis, a respiratory failure. This lung...

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Detalles Bibliográficos
Autores principales: Moon, Seungtae, Im, Sun-Kyoung, Kim, Nackhyoung, Youn, Hyesook, Park, Ui-Hyun, Kim, Joo-Yeon, Kim, A.-Reum, An, So-Jung, Kim, Ji-Hoon, Sun, Woong, Hwang, Jin-Taek, Kim, Eun-Joo, Um, Soo-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215009/
https://www.ncbi.nlm.nih.gov/pubmed/30389914
http://dx.doi.org/10.1038/s41419-018-1171-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215009/
https://www.ncbi.nlm.nih.gov/pubmed/30389914
http://dx.doi.org/10.1038/s41419-018-1171-z

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