Cargando…

Purification and Characterization of JZTx-14, a Potent Antagonist of Mammalian and Prokaryotic Voltage-Gated Sodium Channels

Exploring the interaction of ligands with voltage-gated sodium channels (Na(V)s) has advanced our understanding of their pharmacology. Herein, we report the purification and characterization of a novel non-selective mammalian and bacterial Na(V)s toxin, JZTx-14, from the venom of the spider Chilobra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jie, Tang, Dongfang, Liu, Shuangyu, Hu, Haoliang, Liang, Songping, Tang, Cheng, Liu, Zhonghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215091/ https://www.ncbi.nlm.nih.gov/pubmed/30308978 http://dx.doi.org/10.3390/toxins10100408

Ejemplares similares

Molecular Surface of JZTX-V (β-Theraphotoxin-Cj2a) Interacting with Voltage-Gated Sodium Channel Subtype Na(V)1.4
por: Luo, Ji, et al.
Publicado: (2014)

Electrophysiological and Pharmacological Analyses of Na(v)1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System
por: Zhou, Xi, et al.
Publicado: (2017)

Voltage-gated sodium channels in the mammalian heart
por: Zimmer, Thomas, et al.
Publicado: (2014)

Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
por: Strege, Peter R, et al.
Publicado: (2023)

Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V
por: Dehong, Xu, et al.
Publicado: (2022)

Lysine and the Na(+)/K(+) Selectivity in Mammalian Voltage-Gated Sodium Channels
por: Li, Yang, et al.
Publicado: (2016)

Shellfish Toxins Targeting Voltage-Gated Sodium Channels
por: Zhang, Fan, et al.
Publicado: (2013)

JZTX-V Targets the Voltage Sensor in Kv4.2 to Inhibit I(to) Potassium Channels in Cardiomyocytes
por: Zhang, Yiya, et al.
Publicado: (2019)

Mechanism of Ion Permeation in Mammalian Voltage-Gated Sodium Channels
por: Mahdavi, Somayeh, et al.
Publicado: (2015)

Structural model of the open–closed–inactivated cycle of prokaryotic voltage-gated sodium channels
por: Bagnéris, Claire, et al.
Publicado: (2015)

Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels
por: Finol-Urdaneta, Rocio K., et al.
Publicado: (2019)

Voltage-gated sodium channels assemble and gate as dimers
por: Clatot, Jérôme, et al.
Publicado: (2017)

Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA
por: Finol-Urdaneta, Rocio K., et al.
Publicado: (2019)

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor
por: Adachi, Kanna, et al.
Publicado: (2019)

The Venom of the Spider Selenocosmia Jiafu Contains Various Neurotoxins Acting on Voltage-Gated Ion Channels in Rat Dorsal Root Ganglion Neurons
por: Hu, Zhaotun, et al.
Publicado: (2014)

Engineering of highly potent and selective HNTX-III mutant against hNa(v)1.7 sodium channel for treatment of pain
por: Zhang, Yunxiao, et al.
Publicado: (2021)

Screening for Voltage-Gated Sodium Channel Interacting Peptides
por: Meng, Er, et al.
Publicado: (2014)

Detailed Analysis of (−)-Palmyrolide A and Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists
por: Mehrotra, Suneet, et al.
Publicado: (2014)

Molecular mechanisms of centipede toxin SsTx-4 inhibition of inwardly rectifying potassium channels
por: Tang, Dongfang, et al.
Publicado: (2021)

Spider venom-derived peptide JZTX-14 prevents migration and invasion of breast cancer cells via inhibition of sodium channels
por: Wu, Wenfang, et al.
Publicado: (2023)

Fenestropathy of Voltage-Gated Sodium Channels
por: Gamal El-Din, Tamer M., et al.
Publicado: (2022)

Development and Function of the Voltage-Gated Sodium Current in Immature Mammalian Cochlear Inner Hair Cells
por: Eckrich, Tobias, et al.
Publicado: (2012)

Pharmacological characterization of potent and selective Na(V)1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V
por: Moyer, Bryan D., et al.
Publicado: (2018)

Molecular mechanism of the spider toxin κ-LhTx-I acting on the bacterial voltage-gated sodium channel NaChBac
por: Xiao, Zhen, et al.
Publicado: (2022)

Excitability Constraints on Voltage-Gated Sodium Channels
por: Angelino, Elaine, et al.
Publicado: (2007)

Neurological perspectives on voltage-gated sodium channels
por: Eijkelkamp, Niels, et al.
Publicado: (2012)

Overview of the voltage-gated sodium channel family
por: Yu, Frank H, et al.
Publicado: (2003)

Cannabidiol interactions with voltage-gated sodium channels
por: Sait, Lily Goodyer, et al.
Publicado: (2020)

Calmodulin Interactions with Voltage-Gated Sodium Channels
por: Wu, Xin, et al.
Publicado: (2021)

Structural Advances in Voltage-Gated Sodium Channels
por: Jiang, Daohua, et al.
Publicado: (2022)

Phosphoinositide regulation of voltage-gated sodium channels
por: Short, Ben
Publicado: (2023)

Propofol inhibits prokaryotic voltage-gated Na(+) channels by promoting activation-coupled inactivation
por: Yang, Elaine, et al.
Publicado: (2018)

Voltage-Gated Calcium Channel Antagonists and Traumatic Brain Injury
por: Gurkoff, Gene, et al.
Publicado: (2013)

VGSC-DB: an online database of voltage-gated sodium channels
por: Wang, Gaoang, et al.
Publicado: (2022)

Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain
por: Zeng, Xiongzhi, et al.
Publicado: (2018)

Voltage-gated sodium channels in taste bud cells
por: Gao, Na, et al.
Publicado: (2009)

THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL
por: Payandeh, Jian, et al.
Publicado: (2011)

Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels
por: Stevens, Marijke, et al.
Publicado: (2011)

Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels
por: Peigneur, Steve, et al.
Publicado: (2014)

Marine Toxins That Target Voltage-gated Sodium Channels
por: Al-Sabi, Ahmed, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_depetefkr1e2hh1hmbe3o26s2q